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Article

CRISPR-Suppressor Scanning for Systematic Discovery of Drug-Resistance Mutations.

Current protocols - 1 Dec 2022

Ngan Kevin C, Lue Nicholas Z, Lee Ceejay, Liau Brian B

Abstract excerpt

CRISPR-Cas9 genome editing technologies have enabled complex genetic manipulations in situ, including large-scale, pooled screening approaches to probe and uncover mechanistic insights across various biological processes. The RNA-programmable nature of CRISPR-Cas9 greatly empowers tiling mutagenesis approaches to elucidate molecular details of protein function, in particular the interrogation of mechanisms of...

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PMID: 36541895
DOI: 10.1002/cpz1.614
PMCID: PMC10073897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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