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Article

New strategies for targeting drug combinations to overcome mutation-driven drug resistance.

Seminars in cancer biology - 1 Feb 2017

Wang Linyan, Wang Haiyun, Song Dongli, Xu Menglin, Liebmen Michael

Abstract excerpt

Targeted therapies are suggested as an effective alternative for patients with cancer that harbor mutations, but treatment outcomes are frequently limited by primary or acquired drug resistance. The present review describes potential mechanisms of primary or acquired drug resistances to provide a resource for considering how to be overcome. We focus on strategies of targeted drug combinations to minimize the...

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PMID: 27840276
DOI: 10.1016/j.semcancer.2016.11.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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