Article

New Protein Function Characterization for Human Paralog Discovery, Scraping the Bottom of the Genomics Barrel

2026-05-31

Abstract excerpt

Increasing the number of related protein paralogs is important for fully understanding protein relationships, yet it remains challenging for sequences in the twilight zone. Here, we present an integrated homolog detection framework that combines sequence-based (BLASTp, MMseqs2), structure-based (Foldseek), and embedding-distance-based (PROST) similarity metrics to identify additional paralogs. To characterize func...

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Literature Corpus work: 54c4b951-ead7-578f-ac5b-3edca53f8e09
DOI: 10.64898/2026.05.28.728578

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