KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases

Abstract excerpt

Protein kinases are among the largest druggable family of signaling proteins, involved in various human diseases, including cancers and neurodegenerative disorders. Despite their clinical relevance, nearly 30% of the 545 human protein kinases remain highly understudied. Comparative genomics is a powerful approach for predicting and investigating the functions of understudied kinases. However, an incomplete knowled...

Topics

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• Receptors, Platelet-Derived Growth Factor
• Position-Specific Scoring Matrices
• Protein Interaction Domains and Motifs
• Protein Kinase C beta
• Protein Kinases
• Protein Processing, Post-Translational
• Receptors, Fibroblast Growth Factor
• Sequence Analysis

Identifiers and source

Literature Corpus work

293684ca-0562-5aae-8ef8-752750d1fdf8

DOI

10.1101/2021.03.05.434161