Article

Accurate Identification of Functional Residues Across the Human Proteome with TAMALE

2026-05-29

Abstract excerpt

The central challenge of the post-AlphaFold era is the ‘functional gap’. Despite having structure predictions for nearly every human protein, we remain unable to systematically distinguish residues that drive activity from those that merely maintain structural integrity. Here we introduce TAMALE, a machine learning model that calculates graded residue-level functional scores across the human proteome without prior...

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Literature Corpus work: b73586e2-f099-5a9e-8b2d-1596812f5571
DOI: 10.64898/2026.05.28.728550

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