Article

Novel universal domain-centric method for protein classification

2025-04-02

Abstract excerpt

Human protein kinases constitute a large superfamily of about 500 genes, historically classified into subfamilies based on phylogenetic relationship. However, many kinases remain unclassified. Phylogeny is typically based on multiple sequence alignments, and neglects the physico-chemical properties of residues at each position of the sequence. By incorporating these properties, we can gain deeper insights beyond b...

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Literature Corpus work: 54d94a7b-c86c-533c-bd1d-2f3a24377f5c
DOI: 10.1101/2025.03.28.645719

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