Article

Potent neutralization of Marburg virus by a vaccine-elicited monoclonal antibody

2025-05-18

Abstract excerpt

Marburg virus (MARV) is a filovirus that causes a severe and often lethal hemorrhagic fever. Despite the increasing frequency of MARV outbreaks, no vaccines or therapeutics are licensed for use in humans. Here, we designed mutations that improve the expression and thermostability of the prefusion MARV glycoprotein (GP) ectodomain trimer, which is the sole target of neutralizing antibodies and vaccines in developme...

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Literature Corpus work: 5495292a-53e6-5b2c-b58b-c14b1e5af77e
DOI: 10.1101/2025.05.14.654121

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