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Article

Potent neutralization of Marburg virus by a vaccine-elicited antibody.

Nature - 1 Feb 2026

Addetia Amin, Perruzza Lisa, Sprouse Kaitlin, Park Young-Jun, McCallum Matthew, Stewart Cameron, Partini Bianca, Brown Jack T, Donati Alessia, Culap Katja, Balmelli Alessio, Chawla Bhavna, Kar Swagata, Gazi Michal, Alfson Kendra, Goez-Gazi Yenny, Carrion Ricardo, Corti Davide, Benigni Fabio, Veesler David

Abstract excerpt

Marburg virus (MARV) is a filovirus that causes severe and often lethal haemorrhagic fever1,2. Despite the increasing frequency of MARV outbreaks, no vaccines or therapeutics are licensed for use in humans. Here we designed mutations that improve the expression, thermostability and immunogenicity of the prefusion MARV glycoprotein (GP) ectodomain trimer, which is the sole target of neutralizing antibodies and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41225006
DOI: 10.1038/s41586-025-09868-1
PMCID: PMC12893919

Genes

GP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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