Article

Discovery of potent cross-neutralizing antibodies for the treatment of Marburg virus disease

2025-08-04

Abstract excerpt

<title>Abstract</title> <p>Marburg virus (MARV) and Ravn virus (RAVV) are highly pathogenic filoviruses that cause Marburg virus disease (MVD), for which no approved treatment currently exists. In this study, we describe a panel of 10 novel mouse-derived monoclonal antibodies (mAbs), all exhibiting neutralizing activity against MARV. Notably, five of these mAbs also cross-neutralize RAVV. Based on amino acid sequ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cfb2f8cb-5731-5f81-a559-25f087225362
DOI: 10.21203/rs.3.rs-7102720/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovery of potent cross-neutralizing antibodies for the treatment of Marburg virus diseaseDOI 10.21203/rs.3.rs-7102720/v1Read

Potent neutralization of Marburg virus by a vaccine-elicited monoclonal antibodySemantic proximity Read

Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPsSemantic proximity Read

Potent neutralization of Marburg virus by a vaccine-elicited antibody.Semantic proximity Read

Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus GlycoproteinSemantic proximity Read

Mechanism of human antibody-mediated neutralization of Marburg virus.Semantic proximity Read

Generation and characterization of protective antibodies to Marburg virusSemantic proximity Read

A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoproteinSemantic proximity Read

The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor BindingSemantic proximity Read

Novel mutations in Marburg virus glycoprotein associated with viral evasion from antibody mediated immune pressure.Semantic proximity Read

Newly isolated mAbs broaden the neutralizing epitope in murine norovirus.Semantic proximity Read

Designing a novel and combinatorial multi-antigenic epitope-based vaccine “MarVax” against Marburg virus—a reverse vaccinology and immunoinformatics approachSemantic proximity Read

Near-germline human monoclonal antibodies neutralize and protect against multiple arthritogenic alphavirusesSemantic proximity Read