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Article

Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers.

Cell reports - 31 Mar 2020

Rutten Lucy, Gilman Morgan S A, Blokland Sven, Juraszek Jarek, McLellan Jason S, Langedijk Johannes P M

Abstract excerpt

Ebola virus causes severe hemorrhagic fever, often leading to death in humans. The trimeric fusion glycoprotein (GP) is the sole target for neutralizing antibodies and is the major focus of vaccine development. Soluble GP ectodomains are unstable and mostly monomeric when not fused to a heterologous trimerization domain. Here, we report structure-based designs of Ebola and Marburg GP trimers based on a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32234486
DOI: 10.1016/j.celrep.2020.03.025
PMCID: PMC7118701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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