Article
Discovery of Marburg virus neutralizing antibodies from virus-naïve human antibody repertoires using large-scale structural predictions.
Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 2020
Bozhanova Nina G, Sangha Amandeep K, Sevy Alexander M, Gilchuk Pavlo, Huang Kai, Nargi Rachel S, Reidy Joseph X, Trivette Andrew, Carnahan Robert H, Bukreyev Alexander, Crowe James E, Meiler Jens
Abstract excerpt
Marburg virus (MARV) disease is lethal, with fatality rates up to 90%. Neutralizing antibodies (Abs) are promising drug candidates to prevent or treat the disease. Current efforts are focused in part on vaccine development to induce such MARV-neutralizing Abs. We analyzed the antibody repertoire from healthy unexposed and previously MARV-infected individuals to assess if naïve repertoires contain suitable...
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