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Anti-Ebola virus mAb 3A6 with unprecedented potency protects highly viremic animals from fatal outcome and physically lifts its glycoprotein target from the virion membrane

2023-12-22

Abstract excerpt

<title>Abstract</title> <p>Monoclonal antibodies (mAbs) against Ebola virus (EBOV) glycoprotein (GP<sub>1,2</sub>) are the standard of care for Ebola virus disease (EVD). Anti-GP<sub>1,2</sub> mAbs targeting the stalk and membrane proximal external region (MPER) potently neutralize EBOV <italic>in vitro</italic>. However, their neutralization mechanism is poorly understood because they target a GP<sub>1,2</sub> e...

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Literature Corpus work
a3a7ac13-0d35-50c1-9cfd-7f14a58299d4
DOI
10.21203/rs.3.rs-3722563/v1
Open publication

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Anti-Ebola virus mAb 3A6 with unprecedented potency protects highly viremic animals from fatal outcome and physically lifts its glycoprotein target from the virion membraneDOI 10.21203/rs.3.rs-3722563/v1
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