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Article

Mechanism of human antibody-mediated neutralization of Marburg virus.

Cell - 26 Feb 2015

Flyak Andrew I, Ilinykh Philipp A, Murin Charles D, Garron Tania, Shen Xiaoli, Fusco Marnie L, Hashiguchi Takao, Bornholdt Zachary A, Slaughter James C, Sapparapu Gopal, Klages Curtis, Ksiazek Thomas G, Ward Andrew B, Saphire Erica Ollmann, Bukreyev Alexander, Crowe James E

Abstract excerpt

The mechanisms by which neutralizing antibodies inhibit Marburg virus (MARV) are not known. We isolated a panel of neutralizing antibodies from a human MARV survivor that bind to MARV glycoprotein (GP) and compete for binding to a single major antigenic site. Remarkably, several of the antibodies also bind to Ebola virus (EBOV) GP. Single-particle EM structures of antibody-GP complexes reveal that all of the...

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Identifiers

PMID: 25723164
DOI: 10.1016/j.cell.2015.01.031
PMCID: PMC4344968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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