HuBIE: The Human Blood Immunome Encyclopedia Of TCRs and BCRs in Bloodstream Infections and Cancer

Abstract excerpt

T and B cells are central to adaptive immunity, where they identify and neutralize foreign antigens and cancer neo–antigens. Large–scale elucidation of T– and B–cell receptors (TCRs and BCRs) through immune–repertoire sequencing promises novel diagnostics, prognostic markers, and therapeutic strategies. However, progress is hampered by small cohort sizes, a lack of real–world patient diversity, and heterogeneous s...

Topics

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• Cancer Immunotherapy and Biomarkers
• CAR-T cell therapy research
• High-Throughput Nucleotide Sequencing
• Immune Cell Function and Interaction
• Monoclonal and Polyclonal Antibodies Research
• Receptors, Antigen, T-Cell, alpha-beta
• T-cell and B-cell Immunology
• T-Lymphocytes

Identifiers and source

Literature Corpus work

b96eb0c9-6645-5951-8083-9cd859750fa5

DOI

10.1101/2025.10.22.678684