Article

Thrifty wide-context models of B cell receptor somatic hypermutation

2024-12-01

Abstract excerpt

Somatic hypermutation (SHM) is the diversity-generating process in antibody affinity maturation. Probabilistic models of SHM are needed for analyzing rare mutations, for understanding the selective forces guiding affinity maturation, and for understanding the underlying biochemical process. High throughput data offers the potential to develop and fit models of SHM on relevant data sets. In this paper we model SHM...

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Literature Corpus work: 5435a7ad-47c7-50fb-890b-c551ebc150f8
DOI: 10.1101/2024.11.26.625407

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