Article

Nucleotide context models outperform protein language models for predicting antibody affinity maturation

2025-06-18

Abstract excerpt

Antibodies play a crucial role in adaptive immunity. They develop as B cell receptors (BCRs): membrane-bound forms of antibodies that are expressed on the surfaces of B cells. BCRs are refined through affinity maturation, a process of somatic hypermutation (SHM) and natural selection, to improve binding to an antigen. Computational models of affinity maturation have developed from two main perspectives: molecular...

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Literature Corpus work: bb39c59f-4fd9-5c83-a6bb-62e445748530
DOI: 10.1101/2025.06.16.659977

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