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Article

Rapid, population-wide declines in stem cell number and activity during reproductive aging in C. elegans

1 Jan 2019

Abstract excerpt

C. elegans hermaphrodites display dramatic age-related decline of reproduction early in life while somatic functions are still robust. To understand reproductive aging, we analyzed the assembly line of oocyte production that generates fertilized eggs. Aging germlines displayed both sporadic and population-wide changes. A small fraction of aging animals displayed endomitotic oocytes in the germline and other...

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PMID: 30936182
DOI: 10.1242/dev.173195

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