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Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.

Clinical science (London, England : 1979) - 1 Jun 2017

Dongiovanni Paola, Meroni Marica, Baselli Guido Alessandro, Bassani Giulia Alessandra, Rametta Raffaela, Pietrelli Alessandro, Maggioni Marco, Facciotti Federica, Trunzo Valentina, Badiali Sara, Fargion Silvia, Gatti Stefano, Valenti Luca

Abstract excerpt

In patients with non-alcoholic fatty liver disease (NAFLD), insulin resistance (IR) associates with fibrosis progression independently of the hepatic inflammation, but the mechanisms are still unclear. We modeled the independent contribution of inflammation (non-alcoholic steatohepatitis: NASH) by exploiting the methionine-choline deficient (MCD) diet, and that of IR by insulin receptor (InsR) haploinsufficiency...

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Share to Amino Acid Oxidoreductases
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PMID: 28468951
DOI: 10.1042/CS20170175

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LOXL2

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