Article

Estrogen receptor α phosphorylated at Ser216 confers inflammatory function to mouse microglia

2020-04-14

Abstract excerpt

<h4>Background: </h4> Estrogen receptor α (ERα) has been suggested to regulate anti-inflammatory signaling in brain microglia, the only resident immune cells in the brain. ERα conserves the phosphorylation motif at Ser216 within the DNA binding domain. Previously, Ser216 was found to be phosphorylated in neutrophils infiltrating into the mouse uterus and to enable ERα to regulate migration. Given the implication o...

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Literature Corpus work: 54226bed-fab6-57a6-9983-cb18624819c2
DOI: 10.21203/rs.2.18935/v2

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