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Article

ERα-independent NRF2-mediated immunoregulatory activity of tamoxifen.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Dec 2021

Pepe Giovanna, Sfogliarini Chiara, Rizzello Loris, Battaglia Giuseppe, Pinna Christian, Rovati Gianenrico, Ciana Paolo, Brunialti Electra, Mornata Federica, Maggi Adriana, Locati Massimo, Vegeto Elisabetta

Abstract excerpt

Sex differences in immune-mediated diseases are linked to the activity of estrogens on innate immunity cells, including macrophages. Tamoxifen (TAM) is a selective estrogen receptor modulator (SERM) used in estrogen receptor-alpha (ERα)-dependent breast cancers and off-target indications such as infections, although the immune activity of TAM and its active metabolite, 4-OH tamoxifen (4HT), is poorly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34653752
DOI: 10.1016/j.biopha.2021.112274

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