Article

A P2RY12 Deficiency Results in Sex-specific Cellular Perturbations and Sexually Dimorphic Behavioral Anomalies

2024-03-06

Abstract excerpt

Microglia are sexually dimorphic, yet, this critical aspect is often overlooked in neuroscientific studies. Decades of research have revealed the dynamic nature of microglial-neuronal interactions, but seldom consider how this dynamism varies with microglial sex differences, leaving a significant gap in our knowledge. This study focuses on P2RY12, a highly expressed microglial signature gene that mediates microgli...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1a03fed-2c82-57bb-ab11-4945b76377e2
DOI: 10.21203/rs.3.rs-3997803/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A P2RY12 Deficiency Results in Sex-specific Cellular Perturbations and Sexually Dimorphic Behavioral AnomaliesDOI 10.21203/rs.3.rs-3997803/v1Read

Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia.Semantic proximity Read

The Pathological Activation of Microglia Is Modulated by Sexually Dimorphic Pathways.Semantic proximity Read

Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice.Semantic proximity Read

Microglial P2 Purinergic Receptor and Immunomodulatory Gene Transcripts Vary By Region, Sex, and Age in the Healthy Mouse CNSSemantic proximity Read

Sex-Specific Features of Microglia from Adult Mice.Semantic proximity Read

Transcriptome analysis of microglia in a mouse model of Rett syndrome: differential expression of genes associated with microglia/macrophage activation and cellular stress.Semantic proximity Read

Sexual dimorphism of complement-dependent microglial synaptic pruning and other immune pathways in the developing brainSemantic proximity Read

Shaping Microglial Phenotypes Through Estrogen Receptors: Relevance to Sex-Specific Neuroinflammatory Responses to Brain Injury and Disease.Semantic proximity Read

IRF8 deficiency causes anxiety-like behavior in a sex-dependent mannerSemantic proximity Read

Sex differences in the developing brain as a source of inherent riskSemantic proximity Read

Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During AgingSemantic proximity Read

Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice.Semantic proximity Read