Article

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer’s Disease

2023-07-26

Abstract excerpt

The pathogenesis of Alzheimer’s disease (AD) depends on environmental and heritable factors, with remarkable differences evident between individuals at the molecular level. Here we present a transcriptomic survey of AD using spatial transcriptomics (ST) and single-nucleus RNA-seq in cortical samples from early-stage AD, late-stage AD, and AD in Down Syndrome (AD in DS) donors. Studying AD in DS provides an opportu...

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Literature Corpus work: 541af111-6f46-535c-a957-850b028f8683
DOI: 10.1101/2023.07.24.550282

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