Article

Distinct matrix viscoelasticity in bone fracture hematoma steers macrophage polarization

2025-11-17

Abstract excerpt

Physical properties of the extracellular matrix (ECM) are key regulators of cellular behavior. Following injury, the formation of a hematoma establishes a provisional niche that initiates and regulates healing responses. However, the influence of hematoma viscoelastic properties on immune cell behavior remains poorly understood. Here, we show that distinct ECM viscoelastic properties of the maturing fracture hemat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 541a9e21-763e-5d3f-a18e-fbd273aa3a84
DOI: 10.1101/2025.11.14.688455

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct matrix viscoelasticity in bone fracture hematoma steers macrophage polarizationDOI 10.1101/2025.11.14.688455Read

Viscoelastic Hydrogel Modulates Phenotype of Macrophage-Derived Multinucleated Cells and Macrophage Differentiation in Foreign Body Reactions.Semantic proximity Read

A Conceptual Fascial Memory Reset Hypothesis: Mechanobiological Insights into Stacking Fascia as an Ultrasound-Visible Structural Phenotype and the Potential Role of Fascial HydroreleaseSemantic proximity Read

Hydrogel viscoelasticity regulates human monocyte-derived macrophage morphology and phenotype in 2D culture.Semantic proximity Read

Maladaptive immune-fibrotic axis drives impaired long bone regeneration under mechanical instabilitySemantic proximity Read

A Conceptual Fascial Memory Reset Hypothesis: Mechanobiological Insights into Stacking Fascia as an Ultrasound-Visible Structural Phenotype and the Potential Role of Fascial Hydrorelease.Semantic proximity Read

Biophysical regulation of macrophages in health and diseaseSemantic proximity Read

Single-cell RNA-seq reveals cellular heterogeneity from deep fascia in patients with acute compartment syndromeSemantic proximity Read

The stiffness-sensitive transcriptome of human tendon stromal cellsSemantic proximity Read

Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritisSemantic proximity Read

Magnetic nanocomplexes coupled with an external magnetic field modulate macrophage phenotype – a non-invasive strategy for bone regenerationSemantic proximity Read

Matrix stress-relaxation and stiffness modulate oligodendrocyte differentiationSemantic proximity Read

Extracellular matrix biomechanical roles and adaptation in health and diseaseSemantic proximity Read