Article

Maladaptive immune-fibrotic axis drives impaired long bone regeneration under mechanical instability

2023-10-31

Abstract excerpt

<h4>ABSTRACT</h4> Delayed and non-healing fractures, affecting 5–10% of cases, are associated with prolonged disability and diminished quality of life. Although acute inflammation is required to initiate repair, persistent mechanical instability can sustain maladaptive immune and fibrotic responses that impede regeneration. Existing animal models do not adequately recapitulate mechanical instability, the principa...

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Literature Corpus work: f501c31d-bf82-57c2-ac5f-4c7d06ed7486
DOI: 10.1101/2023.10.26.564177

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