Hydrogel-Based Mechano-Immunomodulation in Bone Fracture Healing: Mechanical Regulation of Macrophage Phenotypes, Osteoimmune Interactions, and Regeneration.

doi:10.1002/cbin.70208

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Article

Hydrogel-Based Mechano-Immunomodulation in Bone Fracture Healing: Mechanical Regulation of Macrophage Phenotypes, Osteoimmune Interactions, and Regeneration.

Cell biology international - 1 Oct 2026

Ramakrishnan Praveen, Thajuddin Nooruddin, Mohamed S B, Vinayagam Saranya, Gnanasekaran Lalitha, D Shanmugapriya, Rajamohan Rajaram, Jalaludeen Abdulkadhar Mohamed, Sundaram Thanigaivel

Abstract excerpt

Bone fracture healing is a meticulously regulated process encompassing the inflammatory, reparative, and remodelling phases. Macrophages serve as pivotal coordinators within this cascade, with their polarisation from pro-inflammatory M1 to proregenerative M2 phenotypes, which play a crucial role in determining the repair outcome. Emerging evidence underscores the significant influence of mechanical cues such as...

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Topics

Humans
Fracture Healing
Macrophages
Mechanotransduction, Cellular
Animals

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Bone Regeneration

Hydrogels

Immunomodulation

Biocompatible Materials

Phenotype

Fractures, Bone

Mesenchymal Stem Cells

Source

Open in PubMed

Identifiers

PMID: 42765521
DOI: 10.1002/cbin.70208

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