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Article

Viscoelastic Hydrogel Modulates Phenotype of Macrophage-Derived Multinucleated Cells and Macrophage Differentiation in Foreign Body Reactions.

Journal of biomedical materials research. Part A - 1 Jan 2025

Fang Josephine Y, Yang Zhi, Hu Wei, Hoang Ba Xuan, Han Bo

Abstract excerpt

Biomaterial-induced macrophage-derived multinucleated cells (MNCs) are often observed at or near material implantation sites, yet their subtypes and roles in tissue repair and wound healing remain unclear. This study compares material-induced MNCs to cytokine-induced MNCs using both in vitro and in vivo models. 3D-embedded Raw264.7 cells and rat bone marrow-derived monocytes (BMDMs), with or without cytokines...

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Elasticity
Giant Cells
Hydrogels
Macrophages
Osteoclasts

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Rats, Sprague-Dawley

RAW 264.7 Cells

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PMID: 39429027
DOI: 10.1002/jbm.a.37814

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