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Hydrogel viscoelasticity regulates human monocyte-derived macrophage morphology and phenotype in 2D culture.

Acta biomaterialia - 1 Jun 2026

Coser Consuelo, di Bari Vincenzo, Ghaemmaghami Amir M, Yang Jing

Abstract excerpt

Macrophages are a key cell type in the foreign body reaction (FBR), playing a central role in the inflammatory response to implanted biomaterials and in fibrous capsule formation. However, the influence of biomaterial viscoelasticity on macrophages remains poorly understood. Only a very limited number of studies have investigated the viscoelastic-macrophage interactions, using cell lines or murine cells with...

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PMID: 42025986
DOI: 10.1016/j.actbio.2026.04.032

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