Article

CoDIAC: A comprehensive approach for interaction analysis reveals novel insights into SH2 domain function and regulation

2024-07-22

Abstract excerpt

Protein domains are conserved structural and functional units that serve as building blocks of proteins. Through evolutionary expansion, domain families are represented by multiple members in diverse configurations with other domains, evolving new specificities for their interacting partners. Here, we develop a structure-based interface analysis to comprehensively map domain interfaces from experimental and predic...

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Literature Corpus work: 9a95cac3-6afd-58a9-b1fc-f3c926840597
DOI: 10.1101/2024.07.18.604100

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