Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SH2db, an information system for the SH2 domain

19 May 2023

Abstract excerpt

SH2 domains are key mediators of phosphotyrosine-based signalling, and therapeutic targets for diverse, mostly oncological, disease indications. They have a highly conserved structure with a central beta sheet that divides the binding surface of the protein into two main pockets, responsible for phosphotyrosine binding (pY pocket) and substrate specificity (pY + 3 pocket). In recent years, structural databases...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to PI3K/AKT/mTOR signaling in cancer
Share to Protein Tyrosine Phosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37207333
DOI: 10.1093/nar/gkad420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SH2db, an information system for the SH2 domainPMID 37207333Read ↗

A Systematic Compilation of Human SH3 Domains: A Versatile Superfamily in Cellular SignalingSemantic proximity Read ↗

CoDIAC: A comprehensive approach for interaction analysis reveals novel insights into SH2 domain function and regulationSemantic proximity Read ↗

Diversity in the SH2 domain family phosphotyrosyl peptide binding site.Semantic proximity Read ↗

Genome wide analysis of pathogenic SH2 domain mutations.Semantic proximity Read ↗

[The Biological Function of SHP2 in Human Disease].Semantic proximity Read ↗

Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical SpecificitiesSemantic proximity Read ↗

SpY-C: Supervised Learning of Phosphopeptide Sequence Constraints Enables Global Prediction of SH2 Domain BindingSemantic proximity Read ↗

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling.Semantic proximity Read ↗

Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 PhosphataseSemantic proximity Read ↗

Surface Loops in a Single SH2 Domain Are Capable of Encoding the Spectrum of Specificity of the SH2 Family.Semantic proximity Read ↗

Relationship between SPRY and B30.2 protein domains. Evolution of a component of immune defence?Semantic proximity Read ↗

High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide displaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.