Article

The selective 5-HT <sub>1A</sub> receptor biased agonist, NLX-101, corrects anomalous behavioral phenotype in a mouse model of Fragile X syndrome

2025-09-17

Abstract excerpt

<h4>ABSTRACT</h4> Fragile X syndrome (FXS) is the most prevalent X-linked dominant autism spectrum disorder, causing a range of developmental problems, notably characterized by mild to severe mood/cognitive dysfunctions. NLX-101 is a highly selective and fully efficacious biased agonist at post-synaptic 5-HT 1A receptors, and has shown efficacy for reversal of sensory hypersensitivity and EEG anomalies in transg...

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Literature Corpus work: 5405f600-a372-51ec-8a99-1072d6dc22b3
DOI: 10.1101/2025.09.16.676519

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