Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy.

doi:10.1038/s41598-021-94079-7

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Article

Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy.

Scientific reports - 25 Aug 2021

Reyes Samantha T, Deacon Robert M J, Guo Scarlett G, Altimiras Francisco J, Castillo Jessa B, van der Wildt Berend, Morales Aimara P, Park Jun Hyung, Klamer Daniel, Rosenberg Jarrett, Oberman Lindsay M, Rebowe Nell, Sprouse Jeffrey, Missling Christopher U, McCurdy Christopher R, Cogram Patricia, Kaufmann Walter E, Chin Frederick T

Abstract excerpt

Fragile X syndrome (FXS), a disorder of synaptic development and function, is the most prevalent genetic form of intellectual disability and autism spectrum disorder. FXS mouse models display clinically-relevant phenotypes, such as increased anxiety and hyperactivity. Despite their availability, so far advances in drug development have not yielded new treatments. Therefore, testing novel drugs that can ameliorate...

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PMID: 34433831
DOI: 10.1038/s41598-021-94079-7
PMCID: PMC8387417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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