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Article

Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.

Neuron - 12 Apr 2012

Michalon Aubin, Sidorov Michael, Ballard Theresa M, Ozmen Laurence, Spooren Will, Wettstein Joseph G, Jaeschke Georg, Bear Mark F, Lindemann Lothar

Abstract excerpt

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. Previous studies have implicated mGlu5 in the pathogenesis of the disease, but a crucial unanswered question is whether pharmacological mGlu5 inhibition is able to reverse an already established FXS phenotype in mammals. Here we have used the novel, potent, and selective mGlu5 inhibitor CTEP to address this issue in the Fmr1...

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Identifiers

PMID: 22500629
DOI: 10.1016/j.neuron.2012.03.009
PMCID: PMC8822597

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