Article
Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule.
Orphanet journal of rare diseases - 1 Aug 2014
Hébert Betty, Pietropaolo Susanna, Même Sandra, Laudier Béatrice, Laugeray Anthony, Doisne Nicolas, Quartier Angélique, Lefeuvre Sandrine, Got Laurence, Cahard Dominique, Laumonnier Frédéric, Crusio Wim E, Pichon Jacques, Menuet Arnaud, Perche Olivier, Briault Sylvain
Abstract excerpt
BACKGROUND: Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability and is also associated with autism spectrum disorders. Previous studies implicated BKCa channels in the neuropathogenesis of FXS, but the main question was whether pharmacological BKCa stimulation would be able to rescue FXS neurobehavioral phenotypes. METHODS AND RESULTS: We used a selective BKCa channel opener...
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