Spatially discrete signalling niches regulate fibroblast heterogeneity in human lung cancer

Abstract excerpt

Fibroblasts are functionally heterogeneous cells, capable of promoting and suppressing tumour progression. Across cancer types, the extent and cause of this phenotypic diversity remains unknown. We used single-cell RNA sequencing and multiplexed immunohistochemistry to examine fibroblast heterogeneity in human lung and non-small cell lung cancer (NSCLC) samples. This identified seven fibroblast subpopulations: inc...

Topics

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• Cancer Cells and Metastasis
• Chronic Obstructive Pulmonary Disease (COPD) Research
• Congenital Diaphragmatic Hernia Studies
• Fibroblast Growth Factor Research
• Lung
• Neonatal Respiratory Health Research
• Pancreatic and Hepatic Oncology Research
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

ec2384f2-ad6f-5522-b7aa-765163b45b01

DOI

10.1101/2020.06.08.134270