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Article

Computational model predicts paracrine and intracellular drivers of fibroblast phenotype after myocardial infarction.

Matrix biology : journal of the International Society for Matrix Biology - 1 Sept 2020

Zeigler Angela C, Nelson Anders R, Chandrabhatla Anirudha S, Brazhkina Olga, Holmes Jeffrey W, Saucerman Jeffrey J

Abstract excerpt

The fibroblast is a key mediator of wound healing in the heart and other organs, yet how it integrates multiple time-dependent paracrine signals to control extracellular matrix synthesis has been difficult to study in vivo. Here, we extended a computational model to simulate the dynamics of fibroblast signaling and fibrosis after myocardial infarction (MI) in response to time-dependent data for nine paracrine...

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Identifiers

PMID: 32209358
DOI: 10.1016/j.matbio.2020.03.007
PMCID: PMC7434705

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