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Article

Genetic variation drives cancer cell adaptation to ECM stiffness.

Proceedings of the National Academy of Sciences of the United States of America - 24 Sept 2024

Wang Ting-Ching, Sawhney Suchitaa, Morgan Daylin, Bennett Richard L, Rashmi Richa, Estecio Marcos R, Brock Amy, Singh Irtisha, Baer Charles F, Licht Jonathan D, Lele Tanmay P

Abstract excerpt

The progression of many solid tumors is accompanied by temporal and spatial changes in the stiffness of the extracellular matrix (ECM). Cancer cells adapt to soft and stiff ECM through mechanisms that are not fully understood. It is well known that there is significant genetic heterogeneity from cell to cell in tumors, but how ECM stiffness as a parameter might interact with that genetic variation is not known....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39302966
DOI: 10.1073/pnas.2403062121
PMCID: PMC11441511

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