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Article

An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2.

Biochemical and biophysical research communications - 29 Nov 2002

Tao Xiao, Xu Yingwu, Zheng Ye, Beg Amer A, Tong Liang

Abstract excerpt

The Toll/interleukin-1 receptor (TIR) domains are conserved modules in the intracellular regions of the Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). The domains are crucial for the signal transduction by these receptors, through homotypic interactions among the receptor and the downstream adapter TIR domains. Previous studies showed that the BB loop in the structure of the TIR domain forms a...

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Source

Identifiers

PMID: 12437972
DOI: 10.1016/s0006-291x(02)02581-0

Genes

TLR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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