Article
An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2.
Biochemical and biophysical research communications - 29 Nov 2002
Tao Xiao, Xu Yingwu, Zheng Ye, Beg Amer A, Tong Liang
Abstract excerpt
The Toll/interleukin-1 receptor (TIR) domains are conserved modules in the intracellular regions of the Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). The domains are crucial for the signal transduction by these receptors, through homotypic interactions among the receptor and th...
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