Article

On a mechanistic impact of transmembrane tetramerization in pathological activation of RTKs

2022-10-15

Abstract excerpt

Constitutive activation of receptor tyrosine kinases (RTKs) via different mutation has a strong impact into development of severe human disorders, including cancer. While pathological effect of such mutations can be common on the phenotypical level, mechanistic understanding of their contribution into the receptor activation depends on the exact molecular context. Mutations in transmembrane (TM) domains represent...

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Literature Corpus work: 508d66ad-8b87-5862-a595-0948435fcef4
DOI: 10.1101/2022.10.14.512270

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