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Article

The pathogenic effect of SNPs on structure and function of human TLR4 using a computational approach.

Journal of biomolecular structure & dynamics - 1 Jan 2023

Prakasam Priya, Abdul Salam Abdul Ajees, Basheer Ahamed Syed Ibrahim

Abstract excerpt

The human toll-like receptor (hTLR) 4 single nucleotide polymorphisms (SNPs) are interconnected with cancer, multiple genetic disorders and other immune-related diseases. The detrimental effect of SNPs in hTLR4 with respect to structure and function has not been explored in depth. The present study concatenates the biological consequences of the SNPs along with structural modifications predicted at the hTLR4...

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PMID: 36648243
DOI: 10.1080/07391102.2023.2166998

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