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Article

Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis.

The Journal of biological chemistry - 22 Feb 2013

Zeng Daina, Zhao Jinshi, Chung Hak Suk, Guan Ziqiang, Raetz Christian R H, Zhou Pei

Abstract excerpt

LpxC, the deacetylase that catalyzes the second and committed step of lipid A biosynthesis in Escherichia coli, is an essential enzyme in virtually all gram-negative bacteria and is one of the most promising antibiotic targets for treatment of multidrug-resistant gram-negative infections. Despite the rapid development of LpxC-targeting antibiotics, the potential mechanisms of bacterial resistance to LpxC...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23316051
DOI: 10.1074/jbc.M112.447607
PMCID: PMC3581379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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