Article
Bioinformatic prospecting and synthesis of a bifunctional lipopeptide antibiotic that evades resistance
26 May 2022
Abstract excerpt
Emerging resistance to currently used antibiotics is a global public health crisis. Because most of the biosynthetic capacity within the bacterial kingdom has remained silent in previous antibiotic discovery efforts, uncharacterized biosynthetic gene clusters found in bacterial genome–sequencing studies remain an appealing source of antibiotics with distinctive modes of action. Here, we report the discovery of a...
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