Article

Antigenic determinants of HAstV-VA1 neutralization and their relevance in the human immune response

2024-03-08

Abstract excerpt

Astroviruses are highly divergent and infect a wide variety of animal hosts. In 2009, a genetically divergent human astrovirus (HAstV) strain VA1 was first identified in an outbreak of acute gastroenteritis. This strain has also been associated with fatal central nervous system disease. In this work, we report the isolation of three high-affinity neutralizing monoclonal antibodies (Nt-MAbs) targeting the capsid sp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 53b36142-3b65-53b5-b210-33357297f663
DOI: 10.1101/2024.03.05.583477

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antigenic determinants of HAstV-VA1 neutralization and their relevance in the human immune responseDOI 10.1101/2024.03.05.583477Read

Mouse and human immune responses share neutralization epitopes of HAstV-VA1.Semantic proximity Read

Structure and antigenicity of the divergent human astrovirus VA1 capsid spike.Semantic proximity Read

Isolation of Neutralizing Monoclonal Antibodies to Human Astrovirus and Characterization of Virus Variants That Escape NeutralizationSemantic proximity Read

Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralizationSemantic proximity Read

Structural Basis for Escape of Human Astrovirus from Antibody Neutralization: Broad Implications for Rational Vaccine Design.Semantic proximity Read

Structure of a Human Astrovirus Capsid-Antibody Complex and Mechanistic Insights into Virus Neutralization.Semantic proximity Read

Structural, Mechanistic, and Antigenic Characterization of the Human Astrovirus CapsidSemantic proximity Read

Structure of the divergent human astrovirus MLB capsid spikeSemantic proximity Read

Molecular evolutionary analysis of type-1 human astroviruses identifies putative sites under selection pressure on the capsid protein.Semantic proximity Read

Characterization of a Human Astrovirus Serotype 2 Structural Protein (VP26) That Contains an Epitope Involved in Virus NeutralizationSemantic proximity Read

Structural Insights into the Human Astrovirus CapsidSemantic proximity Read

Crystal Structure of the Avian Astrovirus Capsid SpikeSemantic proximity Read