Article
Structural Basis for Escape of Human Astrovirus from Antibody Neutralization: Broad Implications for Rational Vaccine Design.
Journal of virology - 1 Jan 2018
Bogdanoff Walter A, Perez Edmundo I, López Tomás, Arias Carlos F, DuBois Rebecca M
Abstract excerpt
Human astroviruses are recognized as a leading cause of viral diarrhea worldwide in children, immunocompromised patients, and the elderly. There are currently no vaccines available to prevent astrovirus infection; however, antibodies developed by healthy individuals during previous infection correlate with protection from reinfection, suggesting that an effective vaccine could be developed. In this study, we...
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