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LTB <sub>4</sub> is converted into a potent human neutrophil NADPH oxidase activator via a receptor transactivation mechanism in which the BLT <sub>1</sub> receptor activates the free fatty acid receptor 2

2024-11-15

Abstract excerpt

The endogenous neutrophil chemoattractant leukotriene B 4 (LTB 4 ) is a biased signalling agonist that potently increases the intracellular concentration of free calcium ions ([Ca 2+ ] i ), but alone is a weak activator of the neutrophil superoxide anion (O 2 - )-generating NADPH oxidase. However, in this study we show that an allosteric modulator of the free fatty acid 2 receptor (FFA2R) converts LTB 4 into...

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Literature Corpus work
53ad5b7c-f34c-5c4e-95ba-e70f9234135d
DOI
10.1101/2024.11.12.623248
Open publication

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LTB <sub>4</sub> is converted into a potent human neutrophil NADPH oxidase activator via a receptor transactivation mechanism in which the BLT <sub>1</sub> receptor activates the free fatty acid receptor 2DOI 10.1101/2024.11.12.623248
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