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Article

CUL4B regulates thyroid cancer differentiation and treatment sensitivity by ubiquitinating ARID1A

11 Apr 2025

Abstract excerpt

• In the current study, for the first time, we dissected the role of CUL4B in TC. • We characterized that CUL4B ubiquitinates and degrades the SWI/SNF complex while competitively binding with ARID1A in the SWI/SNF complex to PAX8 at the transcription initiation site, ultimately leading to the downregulation of PAX8 expression. • A combination of CUL4B inhibitor, trametinib and dabrafenib may lead to more...

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PMID: 40203790
DOI: 10.1016/j.tranon.2025.102389

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