TRIM11 promotes the proliferation, migration and chemoresistance of anaplastic thyroid cancer by stabilizing YAP

Abstract excerpt

<h4>Background: </h4> Anaplastic thyroid cancer (ATC) is one of the most aggressive and virulent solid tumors. The ubiquitin proteasome system presents in all eukaryotic cells and is essential for cellular homeostasis. While its underlying role in ATC remains largely unclear. TRIM11 is an E3 ubiquitin ligase and has been reported to act as an oncogene in several human cancers. The present study aims to reveal the...

Topics

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• Autophagy in Disease and Therapy
• Cancer Mechanisms and Therapy
• Cancer-related Molecular Pathways
• Cytokine Signaling Pathways and Interactions
• interferon and immune responses
• Ocular Diseases and Behçet’s Syndrome
• Toxoplasma gondii Research Studies
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

0e682a7f-b9c8-5cdd-85fa-cf1419e53683

DOI

10.21203/rs.3.rs-40875/v1