Article

The Role of the Human Fc Receptor FcγRIIA in the Immune Clearance of Platelets: A Transgenic Mouse Model

1999-04-01

Abstract excerpt

Abstract In humans, the Fc receptor for IgG, FcγRIIA, is expressed on macrophages and platelets and may play an important role in the pathophysiology of immune-mediated thrombocytopenia. Mice lack the genetic equivalent of human FcγRIIA. To better understand the role of FcγRIIA in vivo, FcγRIIA transgenic mice were generated and characterized. One transgenic mouse line expressed FcγRIIA on platelets and macrophage...

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Literature Corpus work: 5353bf5d-7d73-5225-90db-0a2cd5349336
DOI: 10.4049/jimmunol.162.7.4311

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