Article
TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc Receptor for IgG IIA (FcγRIIA) Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2016
Zhou Yuhang, Abraham Shaji, Renna Stephanie, Edelstein Leonard C, Dangelmaier Carol A, Tsygankov Alexander Y, Kunapuli Satya P, Bray Paul F, McKenzie Steven E
Abstract excerpt
OBJECTIVE: The objective of this study is to investigate the role of T-cell ubiquitin ligand-2 (TULA-2) in the platelet Fc receptor for IgG IIA (FcγRIIA) pathway and in the pathogenesis of heparin-induced thrombocytopenia (HIT). APPROACH AND RESULTS: HIT is a life-threatening thrombotic disease in which IgG antibodies against the heparin-platelet factor 4 complex activate platelets via FcγRIIA. We reported...
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