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Article

Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010

Roopenian Derry C, Christianson Gregory J, Sproule Thomas J

Abstract excerpt

Therapeutic monoclonal antibodies are widely recognized to be a most promising means to treat an increasing number of human diseases, including cancers and autoimmunity. To a large extent, the efficacy of monoclonal antibody treatment is because IgG antibodies have greatly extended persistence in vivo. However, conventional rodent models do not mirror human antibody pharmacokinetics. The key molecule responsible...

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PMID: 20012394
DOI: 10.1007/978-1-60761-058-8_6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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