Article
Transgenic mice expressing human FcgammaRIIa have enhanced sensitivity to induced autoimmune arthritis as well as elevated Th17 cells.
Immunology letters - 4 May 2010
Van de Velde Nicholas C, Mottram Patricia L, Powell Maree S, Lim Bock, Holmdahl Rikard, Hogarth P Mark
Abstract excerpt
The major human Fc receptor, huFcgammaRIIa, is implicated in the development of autoimmune arthritis in humans but until recently has not been studied in mouse models. We evaluated potential roles of FcgammaRIIa by using transgenic mice expressing the receptor. We examined two models of induced autoimmune arthritis pristane-induced arthritis (PIA) and collagen-induced arthritis (CIA) as well as the...
Topics
- Animals
- Arthritis
- Autoimmune Diseases
- Disease Models, Animal
- Flow Cytometry
- Genetic Predisposition to Disease
- Humans
- Interferon-gamma
- Interleukin-17
- Mice
- Mice, Transgenic
- Receptors, IgG
- T-Lymphocytes
- Up-Regulation